What is Saccharomyces boulardii?
Saccharomyces boulardii is a probiotic yeast rather than a bacteria-based probiotic. Because it is naturally resistant to stomach acid and bile, it can safely reach the intestines and remain active. As a result, it has been widely studied for its ability to support digestion, reduce diarrhea, and help maintain overall gut balance. Moreover, its stability makes it a reliable option when the digestive system needs quick support.
Difference Between Probiotics and Saccharomyces boulardii
Traditional probiotics are made from bacteria, which means they can be easily destroyed by antibiotics—because antibiotics specifically target bacterial cells.
On the other hand, Saccharomyces boulardii is a yeast, a type of fungus with a completely different cell structure. Therefore, it is not affected or broken down by antibiotics. For this reason, it can continue to work even during antibiotic use, and it may be especially helpful when regular probiotics are not enough.
Key Characteristics of Saccharomyces boulardii
1. Suppresses the growth of harmful bacteria
2. Improvement of acute diarrhea and various diarrhea-related symptoms
3. Support for Irritable Bowel Syndrome (IBS)
4. Anti-inflammatory Effects
How to Take Saccharomyces boulardii Effectively
Saccharomyces boulardii helps improve the gut environment by creating conditions where helpful bacteria can grow. However, it does not stay in the intestines long-term because it does not colonize the gut.
Therefore, after S. boulardii helps steady the digestive environment, it is important to add probiotics that can actually stay and support long-term balance.
In short, using S. boulardii first and probiotics afterward provides a more complete approach to digestive wellness.
Recommended Supplements for Gut Health
These supplements combine Saccharomyces boulardii—which helps steady the gut environment—with probiotics that add helpful bacteria. Because of this, they offer more complete digestive support. Additionally, each product was carefully developed by pharmacists who selected strains and dosages based on different digestive needs.
YoungLong Yeast Biotics Kids
Children are exposed to fewer types of healthy bacteria, so they often need a broader probiotic blend. For this reason, this formula includes 14 probiotic strains suited to the pediatric gut and 150 mg of S. boulardii to help maintain daily digestive comfort.
- 5 billion CFU guaranteed from 14 strains
- Includes 400 IU of vitamin D
- Contains 150 mg of Saccharomyces boulardii
- Guarantees 5 billion CFU of NorthRelief probiotics
- Banana flavor with minimal additives
YoungLong Yeast Biotics Sensitive
This formula is designed for people with sensitive digestion. It removes unnecessary strains and uses only probiotics that are gentle and effective. Furthermore, it avoids high-FODMAP ingredients that may cause gas or bloating. Instead, it uses only low-FODMAP ingredients and is officially certified for FODMAP compliance.
- 20 billion CFU input, 3 billion CFU guaranteed
- Made with 5 strains suited for sensitive digestion
- Contains 300 mg of Saccharomyces boulardii
- 100% low-FODMAP formulation
- Korea’s first Monash University–certified low-FODMAP product
YoungLong Yeast Biotics Day & Night
This supplement supports the body’s natural day–night rhythm by offering different strains for daytime activity and nighttime recovery. Because of its dual-capsule design, it supports gut balance for a full 24 hours. Additionally, its high CFU input makes it helpful for people with sluggish digestion.
- 100 billion CFU input, 10 billion CFU guaranteed
- Day & night dual capsule system
- Day: Bifidobacterium and Lactobacillus
- Night: Yeast, Kimchi, and Plantarum strains
- Contains 250 mg of Saccharomyces boulardii
FAQ
1. Who May Benefit From Saccharomyces boulardii?
S. boulardii is particularly recommended for:
- Individuals who do not experience improvement even after trying multiple probiotics
- Those who have taken antibiotics long-term or need extended antibiotic therapy
- People with inflammatory bowel condit
2. When is the best time to take Saccharomyces boulardii?
Saccharomyces boulardii does not need to be taken on an empty stomach. Because it is highly resistant to acidic environments such as stomach acid and bile acids, it can be taken even after meals without losing its effectiveness. It also withstands temperatures up to 52°C, which allows it to be stored at room temperature.
References
Below are referenced studies from experts on Saccharomyces boulardii and gut health.
- Wieërs, G. et al. (2021). Do Probiotics During In-Hospital Antibiotic Treatment Prevent Colonization of Gut Microbiota With Multi-Drug-Resistant Bacteria? Frontiers in Public Health.
- Pais, P. et al. (2020). Saccharomyces boulardii: What Makes It Tick as Successful Probiotic? Journal of Fungi. MDPI
- Murzyn, A. et al. (2010). The effect of Saccharomyces boulardii on Candida albicans-infected human intestinal cell lines Caco-2 and Intestin 407. FEMS Microbiology Letters.
- Effectiveness of Saccharomyces boulardii CNCM I-745 probiotic in acute inflammatory viral diarrhoea (2023). BMC Gastroenterology.
- Wang, D. et al. (2025). Therapeutic potential of Saccharomyces boulardii in alleviating gastrointestinal stress through preservation of intestinal cell membrane integrity. BMC Microbiology.
